Matriptase is a cell surface serine protease that belongs to the family by the same name. It is frequently overexpressed in many solid tumor cancers including breast, ovary, uterus, prostate, colon, cervix, and skin cancers. Higher protease activity in these tumors is correlated with more aggressive cancers. Thus a matriptase inhibitor is likely to be a potent anti-tumor drug.
Verseon has developed a series of novel small molecule inhibitors against matriptase.